A cannabinoid that’s even more potent than THC? Introducing THCP, a recently discovered cannabinoid that is shaking up the cannabis industry with its extraordinary potency.

But what exactly is THCP, and what makes this cannabinoid so special? In this article, we’ll dive into what THCP is, explore its potential benefits and risks, discuss its impressive potency, and uncover everything else you need to know about this novelty compound.

Key Takeaways

• THCP is one of the most potent cannabinoids discovered, with a binding affinity to CB1 receptors up to 3 to 5 times stronger than Delta 9 THC. 
• THCP offers recreational benefits, such as heightened euphoria and sensory enhancement, as well as potential medical benefits, such as pain relief, anti-nausea effects, and anxiety reduction.
• Due to its high potency, THCP can lead to more potent side effects, including anxiety, paranoia, and impaired motor skills.
• Users should stay informed about local regulations and be aware of the potential for positive drug tests due to its similarity to THC.
• THCP remains a rare and novel cannabinoid. As more research emerges, it may redefine the landscape of both recreational and therapeutic cannabis use.

What is THCP? 

THCP, or tetrahydrocannabiphorol, is a naturally occurring cannabinoid from a cannabis plant. It was discovered in 2019 and is found in trace amounts, unlike the popular THC and CBD that we’ve all grown to love. Its concentration ranges from approximately 0.0023% to 0.0136% by weight in the flower cluster. 

It exhibits a significantly higher potency compared to Delta 9 THC, with estimates suggesting it may be up to 3 to 5 times more potent when binding to cannabinoid receptors. This heightened potency arises from THCP’s unique chemical structure, particularly its longer alkyl side chain of seven carbon atoms, which enhances its ability to bind to the CB1 and CB2 receptors in the endocannabinoid system. 

Does THCP Get You High?

Yes, THCP does get you high. Initial scientific research suggests that THCP may bind to CB1 receptors in the endocannabinoid system up to 33 times better than THC. While it potentially leads to more pronounced psychoactive effects, humans are limited to feeling THCP’s potency around 3 to 5 times stronger than that of Delta 9 THC. This enhanced interaction with the receptors underscores its potential for more substantial potential therapeutic effects, although more research is required to fully understand its implications in human use.

THCP Potency: Is It the Most Potent Cannabinoid? 

How strong is THCP exactly? If we put it to a THCP vs. THC comparison, THCP’s potency to bind to CB1 receptors with a strength estimated to be 33 times that of Delta 9 THC. But as humans, our receptors are limited to feeling 3 to 5 times its strength. Despite this, it can still get you to another level of “high” if you’re not mindful of your dosage. 

When we compare it to other known cannabinoids, it consistently ranks at the top in potency. It surpasses the effects of Delta 9 THC, which is typically considered the primary psychoactive component in cannabis. Even when compared to other potent cannabinoids like THCO, HHC, and Delta 8 THC, THCP still stands out as potentially more powerful. 

How Long Does THCP’s Effect Last?

The effects of THCP can vary significantly based on three main factors. The potential effects are likely to last longer or shorter depending on the method of consumption, the amount of consumption, and personal tolerance. When inhaled through smoking or vaping, the effects usually last between 2 to 4 hours. 

If you’re taking THCP-infused edibles and tinctures, which are consumed orally, the effects most often last longer, commonly lasting 4 to 6 hours or even longer. This extended duration is primarily due to how THCP is metabolized in the body, as ingested forms undergo a different processing pathway that alters their potency and longevity.

Users intending to try THCP for the first time or with lower tolerance should be mindful of how long they wish to feel the effects when choosing their consumption method. For example, if the user prefers a short and intense impact, then smoking or vaping is the best option. In contrast, when the user wants to feel “high” for longer, tinctures and edibles are the ideal method. 

Users who regularly consume THC or other cannabinoids may have higher tolerance levels, which can lead to less sensitivity to THCP’s effects. Conversely, new THCP users or those with lower tolerance may find that even small doses have notable psychoactive effects, resulting in an overwhelming experience.

Find out more about how long THCP stays in your body and if THCP can lead to positive drug tests for Delta 9 THC.

How is THCP Extracted? 

THCP is a natural cannabinoid but is available in extremely minute amounts. This scarcity made it economically unfeasible for producers to use the plant as the direct source of the compound. So, instead, manufacturers resorted to semi-synthetic methods to produce this on a large scale. 

Raw Material Selection

The process begins with sourcing high-quality hemp strains known for their high CBD content. Selecting appropriate strains is crucial because the quality of CBD extracted directly influences the purity and effectiveness of the resulting THCP. Premium hemp strains are chosen based on stringent potency, purity, and quality criteria, laying a solid foundation for THCP production.

CBD Extraction 

CBD is typically extracted using supercritical CO2 extraction, a method favored for its precision and eco-friendliness. This technique involves using carbon dioxide at specific pressures and temperatures to extract cannabinoids and terpenes from the plant material. Under these conditions, CO2 behaves as a gas and a liquid, efficiently separating desired compounds without leaving harmful residues.

Chemical Conversion to THCP

Once the CBD is extracted, it is converted into THCP through a series of controlled chemical reactions. This process alters the CBD’s molecular structure, extending its alkyl side chain, essential for enhancing its potency. The conversion typically requires specific solvents and reagents under carefully monitored reaction conditions to achieve the desired molecular modifications.

Cyclization of CBD

The first step in the conversion process often involves the cyclization of CBD. This reaction is typically acid-catalyzed and results in the formation of a cyclic structure similar to that of THC. Various acids can be used as catalysts, potentially yielding different results in terms of efficiency and the formation of specific isomers.

Isomerization

Following cyclization, the compound may undergo isomerization. This step can lead to the formation of different THC isomers, including Delta 9 THC and Delta 8 THC. The specific conditions and catalysts used can influence which isomers are predominantly formed. 

Side Chain Modification

The critical step in producing THCP involves extending the alkyl side chain of the THC molecule. This process requires precise chemical manipulation to add carbon atoms to the existing side chain, extending it from five carbon atoms (as in THC) to seven carbon atoms (characteristic of THCP). This extension is what gives THCP its unique properties and increased potency.

Reaction Conditions and Catalysts

The conversion process requires carefully controlled reaction conditions, including specific temperatures, pressures, and durations. Various catalysts and reagents are employed to facilitate the desired chemical transformations. 

Purification Techniques

Following the conversion process, the resulting mixture undergoes purification using chromatography techniques such as high-performance liquid chromatography (HPLC). These methods separate THCP from other compounds based on their molecular weight and polarity, ensuring high purity. The purification process is critical as it removes any residual solvents or impurities that could compromise the quality of the final product. 

In addition to HLPC as a method for THCP isolation, other methods, such as liquid and thin-layer chromatography (TLC), can also be applied. TLC is a simple, cost-effective method for monitoring the purification process of THCP, while liquid chromatography is mainly used for large-scale operations. 

Refinement and Quality Control

After purification, THCP may undergo distillation, further refining, and compound concentration. This step is essential for enhancing the product’s potency and ensuring it meets industry standards for purity and safety. Quality control measures, including third-party lab testing for contaminants and guarantee of dosage accuracy, are integral to the production process, securing consumer safety and satisfaction.

Ways of Consuming THCP 

THCP (Tetrahydrocannabiphorol) can be consumed in various ways, offering different experiences and effects. The most common consumption methods include:

• Vaping and Smoking – THCP can be consumed through vaporizers or vape pens, which allows for quick delivery of the cannabinoid into the body with minimal waste. This method provides fast-acting effects and is popular among users seeking immediate relief or recreational experiences.
• Edibles – THCP-infused edibles, such as gummies, brownies, or chocolates, offer a convenient and discreet consumption method. When ingested, THCP is metabolized by the liver, potentially leading to longer-lasting effects compared to inhalation methods.
• Tinctures and Oils – THCP tinctures and oils can be taken sublingually (under the tongue) for relatively quick absorption into the bloodstream. This method allows for precise dosing and is often preferred by those seeking medicinal benefits.
• Topicals – While less common, THCP is also present in topical forms such as creams, lotions,  or balms, although research on their effectiveness is limited.

Pexels photo by Nataliya Vaitkevich

How Much THCP Should I Consume? 

The following measurements are general recommendations and should be taken with ample caution. Consulting with your healthcare provider or cannabis specialist is highly recommended, especially if you have pre-existing health conditions or are taking other medications. They can provide personalized advice based on your overall health status and needs.

Starting Dose

For those new to THCP, starting with a very low dose is crucial. Experts recommend beginning with 0.3 to 1mg of THCP. This conservative approach allows users to estimate their body’s reaction to this potent cannabinoid without risking overwhelming effects.

Edibles Dosage

Beginners should start with a quarter or half of a gummy, depending on its THCP content, as some manufacturers make 5mg or 10mg variations. Users can take the recommended dosage of 0.3 to 1mg as a safe start. On the other hand, more experienced users might opt for a full gummy but should still exercise caution.

Vaping and Inhalation

• One puff may be sufficient for a threshold effect
• Three or more puffs could lead to more pronounced psychoactive effects
• Users should wait between puffs to assess the impact before taking more

Tinctures and Oils

• Start with 1/4 of a dropper for a threshold dose
• 1/2 or more of a dropper may deliver a more psychoactive effect
• Melting the concentrate under the tongue may lead to a faster onset of effects. 

Gradual Increase

After assessing the initial effects, users can gradually increase their dosage in small increments. It’s advisable to wait at least 2 hours between doses to fully understand the impact before deciding whether to add or pause consumption. Patience is your ally in finding the right balance of safety, personal needs, and tolerance.

Factors Affecting Dosage

• Individual tolerance to cannabinoids
• Body weight and metabolism
• Your desired effects (therapeutic vs. recreational use)
• Method of consumption (edibles, vaping, etc.)

THCP Effects

THCP’s effect varies depending on its intended use, the type of user, and the dosage involved. Anecdotal experiences about recreational and therapeutic THCP effects still need additional scientific testing to be clinically accepted. 

Recreational Benefits 

​THCP is known for producing a more intense high compared to traditional THC, leading users to report elevated and euphoric sensations.​ This heightened psychoactive effect is attributed to its greater binding affinity to cannabinoid receptors, which can result in overwhelming feelings of bliss and relaxation. 

Users often feel sensory enhancement while using THCP. This can include heightened visual, auditory, and tactile sensations, contributing to a more immersive and pleasurable recreational experience. THCP can provide profound relaxation and relief from stress and anxiety, making it appealing for those seeking to unwind after a long day. 

Some users find that it can enhance social interactions. THCP is associated with increased appetite, popularly known as “the munchies.” This can enhance the experience of enjoying food and can promote social dining experiences when using THCP in recreational settings

Therapeutic Benefits 

​THCP has shown significant potential as a pain reliever, with studies indicating it can effectively reduce pain and inflammation.​ Research conducted on mice suggests that THCP is more effective than traditional THC in alleviating pain. It can also combat nausea, especially in patients with chemotherapy. Its binding affinity to cannabinoid receptors could enhance its efficacy in treating nausea and vomiting associated with cancer treatment. 

Anecdotal reports tell us that users experience reduced anxiety and stress, akin to the effects of Delta 9 THC. This could make THCP a helpful option for people seeking relief from anxiety-related disorders. It also serves as an effective treatment for insomnia. Its potential to promote relaxation could help users with disturbed sleeping patterns.

Also, THCP benefits patients experiencing reduced appetites due to medical conditions or treatments as it could act as an appetite stimulant. 

The anti-inflammatory effects of THCP may make it a compelling option for managing conditions characterized by inflammation. Its heightened potency suggests it might provide significant therapeutic benefits in treating various inflammatory disorders.

Some researchers believe that THCP’s heightened potency could translate into more pronounced therapeutic effects compared to traditional THC. As research continues, it is anticipated that THCP might be positioned as a preferred cannabinoid for medical users requiring high levels of THC.

What are the Potential Risks When Consuming THCP? 

The side effects of THCP are not yet fully understood. Since it has several similarities with THC, cannabis enthusiasts believe THCP may produce more intense psychotropic effects than THC because of its higher potency. 

This can result in a greater risk of adverse reactions like:

• Anxiety
• Paranoia
• Dizziness or lethargy
• Decreased motor skills 
• Increased heart rate and blood pressure

Some other minor side effects users mentioned are: 

• Red eyes
• Mood Changes 
• Panic attacks
• Dry mouth
• Headaches
• Altered Perception,
• Difficulty concentrating

While these THCP effects are often short-lived and generally harmless for casual users, excessive consumption may lead to discomfort, prompting the need for moderation and careful dosage management. The risk of experiencing these effects may be higher with THCP, especially for those with lower tolerance or who take larger doses.  Therefore, caution is advised for users, especially those who are new to cannabinoids.

Is THCP Safe? 

Yes, in general, consuming THCP is considered safe. However, THCP is a potent cannabinoid that users should consume with high caution to ensure personal safety. 

Here are some key safety considerations to keep in mind:

• Start with Low Doses – Due to THCP’s significantly higher potency than that of THC, it’s crucial to begin with very low doses. This approach allows your body to acclimate to the compound’s effects and helps users determine the correct dosage without inducing adverse reactions. Overconsumption of THCP can easily lead to undesirable effects, so caution is paramount.
• Be Aware of Potency – THCP is reported to be 3 to 5 times more potent than THC. This enhanced potency means that even small amounts can produce intense psychoactive effects. Users should be prepared for more intense experiences compared to other cannabinoids.
• Consider Individual Factors – Personal factors such as body weight, metabolism, and tolerance levels can influence how your body responds to THCP. These individual variations make it essential to approach THCP use with personalized caution and awareness.
• Choose Reliable Sources – To mitigate potential risks, it’s essential to buy THCP products from reputable sources. Look for products that have undergone third-party laboratory testing to confirm their purity, potency, and absence of harmful contaminants. 
• Be Mindful of How You Consume THCP – Your way of consuming THCP can affect the onset, duration, and intensity of its effects. Inhalation methods like vaping may produce quicker but shorter-lasting effects, while edibles might result in delayed but more prolonged effects. Choose a method that aligns with your experience level and intended use.
• Avoid Mixing with Other Substances – Combining THCP with alcohol, other drugs, or medications can lead to unpredictable and potentially dangerous outcomes. Avoid such combinations at all costs, especially given the limited research on THCP’s interactions with other substances.
• Be Aware Of Side Effects – Users should be aware of potential side effects such as dry mouth, dizziness, anxiety, cognitive impairment, and increased heart rate and blood pressure. If any concerning symptoms persist, seeking medical attention is advisable.
• Use in a Safe Space – Because of its higher potency, using THCP while driving or operating heavy machinery can cause danger to you and the people nearby. It’s a good practice to consume it in familiar settings and with trusted companions so your experience is more enjoyable and less risky.
• Consider Legal Status – The legality of THCP varies by location. Before purchasing or consuming THCP products, make sure you’re aware and compliant with local laws and regulations to avoid legal complications.
• Unknown Long-Term Effects – Given THCP’s recent discovery, the long-term effects of its use still need to be fully discovered. This lack of comprehensive research underscores the need for caution, especially regarding prolonged or frequent use.

Learn more about THCP’s safety profile and tips that consumers can follow. 

Is THCP Legal?

Under federal law, THCP derived from hemp containing less than 0.3% Delta 9 THC is considered legal according to the 2018 Farm Bill. However, this federal stance does not override state-specific laws and regulations.

​The legality of THCP varies significantly across states, with some embracing it while others impose strict regulations or outright bans.​ For example, some states allow some THCP products. Still, other states may prohibit psychoactive cannabinoids entirely, leaving consumers uncertain about their legality in their area or their intended place of travel. 

As consumers engage with THCP products, this risk could lead to job-related consequences or legal issues stemming from drug test failures. The legal status and regulations surrounding THCP are subject to rapid changes. Legislative bodies may pass new laws or evolve existing frameworks, which could affect the availability and legality of THCP products, so it’s important to stay informed. 

Takeaway 

THCP is a potent cannabinoid that has garnered attention for its stronger effects and potential benefits. As research continues to explore its full capabilities, THCP may play an increasingly important role in both recreational and medical cannabis future use. However, its heightened potency also brings risks, particularly to unprepared users for its intense effects. Understanding THCP’s benefits, risks, and potency is crucial for anyone considering its use, whether for enjoyment or therapeutic purposes.

(Disclaimer reminder: This article is not medical advice. It is based on anecdotal user experience alone. If you are thinking about incorporating cannabis (delta-8 THC, delta-9 THC, CBD, etc) into your medicinal routine, please consult a healthcare professional. Do not stop taking any prescribed medications without first consulting your doctor.)

Disclaimer: This article reflects the laws of the United States at the time it was written. Because cannabis laws in the United States are subject to change at any time, please make sure that you are always staying up to date on your federal, state, and local county’s cannabis laws. Additionally, we are NOT encouraging anyone to break the law––we are simply showing people ways to legally and discreetly bring their cannabis products along with them on their travels so that they may have access to those products when they reach their intended destination.

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