- A huge NFC West game between the Los Angeles Rams and San Francisco 49ers takes place on Thursday Night Football in Week 15
- The 49ers have faded to +1000 longshots to make the playoffs while the Rams are +150
- See the Rams vs 49ers odds and picks for TNF on Dec. 12
The San Francisco 49ers (6-7, 4-3 home, 5-8 ATS) are officially in desperation mode with four weeks remaining in the regular season. Last year’s NFC champs are last in the tight NFC West and trail the final Wild Card berth by two games with three teams to leapfrog. On Thursday, the Niners will have a chance to surpass one of those teams when they host the division-rival Los Angeles Rams (7-6, 3-3 away, 6-7 ATS) at Levi Stadium at 5:20 pm PT/8:20 pm ET. The latest NFL odds list the Niners are slight home favorites on Thursday Night Football.
Rams vs 49ers Odds
| Teams | Spread | Moneyline | Total |
|---|---|---|---|
| Los Angeles Rams | +2.5 (+102) | +120 | O 49.5 (-115) |
| San Francisco 49ers | -2.5 (-125) | -150 | U 49.5 (-105) |
The 49ers are 2.5-point or 3.0-point favorites, depending on the sportsbook, and about -150 on the moneyline. The Rams come back as +130 road underdogs. The game total is sitting at 49.5, which is up a full two points from where it opened on Sunday night.
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Odds as of Dec. 11 at ESPN Bet. New users can claim the ESPN Bet promo code to bet on Thursday Night Football in Week 15.
The biggest injury questions on the San Francisco side this week are edge rusher Nick Bosa, who’s questionable with an oblique injury, LT Trent Williams, who’s questionable with an ankle issue, and RB1 Isaac Guerendo, who’s also questionable with a foot injury.
On the Los Angeles sideline, receivers Demarcus Robinson Q and Jordan Whittington are both listed as questionable, along with backup tight end Davis Allen and starting corner Cobie Durant.
The Rams took the first meeting of the season against the Niners, winning 27-24 at home in Week 3, despite San Francisco dominating the yardage battle (425 to 296). The Niners committed the only turnover of the game and missed a field goal that would have given them a 27-17 lead with under three minutes to play in the fourth quarter. Matthew Stafford took full advantage of the miss, marching 55 yards in just three plays to tie the game before a Joshua Karty field goal with two seconds on the clock completed the epic comeback.
Rams vs 49ers H2H: Last Ten Meetings
| Year | Location | Score | Winner |
|---|---|---|---|
| 2024 | LA | 27-24 | Rams |
| 2023 | San Francisco | 21-20 | Rams |
| 2023 | LA | 30-23 | 49ers |
| 2022 | LA | 31-14 | 49ers |
| 2022 | San Francisco | 24-9 | 49ers |
| 2021 | LA | 27-24 OT | 49ers |
| 2021 | San Francisco | 31-10 | 49ers |
| 2020 | LA | 23-20 | 49ers |
| 2020 | San Francisco | 24-16 | 49ers |
| 2021 | San Francisco | 34-31 | 49ers |
LA’s Week 3 victory was their second in a row against the 49ers, but don’t call it a streak, exactly. The other victory was in Week 18 last year when the playoff-bound Niners were resting starters, including QB Brock Purdy. Prior to that game, the 49ers had won nine in a row against their in-state rivals.
Los Angeles Rams vs San Francisco 49ers Picks
I included San Francisco -2.5 among my favorite early Week 15 lines to target and I’m not backing off that handicap now. The Niners are being undervalued based on an injury-driven slump in the middle of the season. They’re still battling some significant injuries – including Christian McCaffrey – but last week’s 38-13 rout of the Bears showed there’s more than enough firepower left on this offense to put up a boatload of points. The Rams have won three straight road games, but only one of those was against a quality opponent (26-20 OT at Seattle).
I’m also betting the over despite it moving up a couple points in the last 72 hours. The Rams’ defense currently rates 20th in the NFL per PFF and was just torched for 42 points by Josh Allen and the Bills. Matthew Stafford and the offense put up 44 in a winning effort but that games was a good indication that the Los Angeles defense is running on fumes. Expect a similar track-meet dynamic in Week 15.
- San Francisco 49ers -2.5 (-125)
- Over 49.5 (-115)
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